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This indicates a strong need for better understanding of the tumor response to the treatment to overcome treatment resistance and reduce tumor progression, as well as to identify therapeutic selectivity, increasing the treatment sensitivity of the tumor while reducing adverse effects in normal tissue [1]

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The transdermal composition of claim 2 which provides at least one of the following release pattern in an In Vitro study employing dialysis membrane and a phosphate buffer of pH 7.4 i) at least 30 % release in 24 hrs and 70 % release in 72 hrs